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We have demonstrated that, following chronic HDM publicity, pericytes detach from the microvasculature and accumulate within the clean muscle bundles of the airways, thus contributing to airway remodelling and lung dysfunction. An established mouse mannequin of asthma driven by power respiratory publicity to house mud mite (HDM) is used to induce persistent allergic bronchial asthma in a way that closely mimics human bronchial asthma. Together, these phenotypic variants characterize a continuous population of cells that mediate vascular tone and contribute to tissue remodelling and repair.
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