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We have demonstrated that, following persistent HDM exposure, pericytes detach from the microvasculature and accumulate inside the easy muscle bundles of the airways, thus contributing to airway remodelling and lung dysfunction. An established mouse model of asthma pushed by continual respiratory publicity to house dust mite (HDM) is used to induce persistent allergic asthma in a means that closely mimics human asthma. Together, these phenotypic variants symbolize a steady population of cells that mediate vascular tone and contribute to tissue remodelling and restore.
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