Barbie was a model in trouble, falling out of step with social norms and unable to re-have interaction with its target market. We have demonstrated that, following continual HDM exposure, pericytes detach from the microvasculature and accumulate inside the clean muscle bundles of the airways, thus contributing to airway remodelling and lung dysfunction. An established mouse model of bronchial asthma driven by continual respiratory exposure to accommodate dust mite (HDM) is used to induce persistent allergic bronchial asthma in a approach that intently mimics human asthma. Together, these phenotypic variants signify a continuous population of cells that mediate vascular tone and contribute to tissue remodelling and repair.
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